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Thursday, April 25, 2013

Realogy Demonstrates Continued Support of the ... - Franchising.com

April 25, 2013 // Franchising.com // MADISON, N.J. - More than two dozen speakers and panelists affiliated with Realogy Holdings Corp. (NYSE: RLGY), a global leader in real estate franchising and provider of real estate brokerage, relocation and settlement services, presented at the Asian Real Estate Association of America?s (AREAA) Global Summit in Honolulu, where 400 attendees from 13 countries were in attendance from April 21-23.

?We welcomed our affiliated brokers who joined us from around the world and, of course, locally from the beautiful islands of Hawaii,? said Tanya Reu, a senior vice president of human resources at Realogy and the AREAA conference chair. ?This event provided attendees with market knowledge, business development opportunities and new relationships to better serve the Asian-American community.?

Below is a list of Realogy-affiliated speakers who presented at the Summit:

? Alex Perriello, President & CEO, Realogy Franchise Group, Panelist, Opening General Session
? Rick Davidson, President & CEO, Century 21 Real Estate, Panelist, Closing General Session
? Philip White, President & CEO, Sotheby?s International Realty Affiliates, Panelist, ?Lifestyles of the Rich and Asian? and speaker at the ?Global Congress?
? Sherry Chris, President & CEO, Better Homes and Gardens Real Estate, Speaker, Opening General Session and Panelist, ?Building a Brokerage of the Future?

?Doing Business in Asia and Around the World? speakers included:

? Ronald Wang, CENTURY 21 Taiwan
? David Carson, Sotheby?s International Realty Canada
? Ryan Lee, CENTURY 21 South Korea
? Kunihiko Omata, CENTURY 21 Mongolia
? Michael Pallier, Sydney Sotheby?s International Realty
? Rick Davidson, Century 21 Real Estate
? Philip White, Sotheby?s International Realty Affiliates

?Business Roundtables? speakers included:

? Rob Mehta, Coldwell Banker Burnet, Minneapolis, Minn.
? Mark Foreman, Century 21 Real Estate
? Brian Krueger, Coldwell Banker Premier Realty, Las Vegas (moderator)
? Christophe Choo, Coldwell Banker Residential Brokerage, Beverly Hills, Calif.
? Tina Mak, Coldwell Banker Westburn Realty, Vancouver
? Kathy Korte, Sotheby?s International Realty, Inc., New York City

?Leading Cities Around the World? speakers included:

? C. Brian Rushton, CENTURY 21 Canada
? Ed Krafchow, Better Homes and Gardens Real Estate Mason-McDuffie, Pleasanton, Calif.
? Dean Jones, Realogics Sotheby?s International Realty, Seattle
? Brett Dickinson, Pacific Sotheby?s International Realty, La Jolla, Calif.
? Jerry Huang, The Corcoran Group, New York City

? Brian Krueger, Coldwell Banker Premier Realty, Las Vegas, Panelist, ?Growing Commercial Real Estate Opportunities?
? Christophe Choo, Coldwell Banker Residential Brokerage, Beverly Hills, Calif., Panelist, ?The Secret to Luxury Listings?
? Kathy Korte, Sotheby?s International Realty Inc., New York City, Panelist, ?The Secret to Luxury Listings?
? Tina Mak, Coldwell Banker Westburn Realty, Vancouver, Panelist, ?How to Reach the Global Consumer?
? Sin-Yi Lambertson, ERA Yes Real Estate, Glendora, Calif., Panelist, ?How to Reach the Global Consumer?
? Herman Chan, Better Homes and Gardens Real Estate Mason-McDuffie, Berkeley, Calif., Panelist, ?Top Agent Panel?

Realogy?s continued involvement with AREAA and its efforts on other diversity-related initiatives are highlighted in the Realogy 2012 Diversity & Community Outreach Report. Founded in 2003, AREAA is a nonprofit professional trade organization dedicated to promoting sustainable homeownership opportunities in Asian American communities by creating a powerful national voice for housing and real estate professionals that serve this dynamic market. More information can be found at www.areaa.org.

About Realogy Holdings Corp.

Realogy Holdings Corp. (NYSE: RLGY) is a global leader in residential real estate franchising with company-owned residential real estate brokerage operations doing business under its franchise systems as well as relocation and title services. Realogy's brands and business units include Better Homes and Gardens? Real Estate, CENTURY 21?, Coldwell Banker?, Coldwell Banker Commercial?, The Corcoran Group?, ERA?, Sotheby's International Realty?, NRT LLC, Cartus and Title Resource Group. Collectively, Realogy's franchise system members operate approximately 13,600 offices with 238,900 independent sales associates doing business in 102 countries around the world. Realogy is headquartered at 175 Park Avenue in Madison, N.J.

SOURCE?Realogy Holdings Corp.

Media Contact:

Kathy Borruso
973 407-5041
Kathy.borruso@realogy.com

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Source: http://www.franchising.com/news/20130425_realogy_demonstrates_continued_support_of_the_asia.html

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Warriors Top Nuggets 131-117: Stephen Curry Scores 30 As Golden State Evens Playoff Series 1-1

DENVER ? The Golden State Warriors hardly missed much of anything Tuesday night.

Not their shots.

Not their injured All-Star.

Stephen Curry had 30 points and 13 assists and the scrappy Warriors handed the Denver Nuggets their first loss at home in more than three months, a 131-117 stunner that evened their playoff series at a game each.

Rallying around injured David Lee, who cheered on the bench in street clothes, the Warriors got 26 points from surprise starter Jarrett Jack, a career-high 24 from rookie Harrison Barnes in his debut at power forward and 21 from Klay Thompson.

The sixth-seeded Warriors, who became the second road team to win in the postseason following Chicago's victory at Brooklyn on Monday, wrested homecourt advantage from the NBA's best home team in the series that shifts to Oakland for Game 3 on Friday night.

"They were knocking down shots," Denver's Andre Iguodala said in an understatement

Better than they ever had before in a playoff game, a franchise playoff-record 64.6 percent from the field (51 of 79).

"We are a very good shooting basketball team," Warriors coach Mark Jackson said. "We've got guys that can knock down shots. You talk about Klay Thompson and Steph Curry, in my opinion, they're the greatest shooting backcourt in the history of the game."

The third-seeded Nuggets were an NBA-best 38-3 at home during the regular season but needed Andre Miller's last-second shot to beat Golden State by a basket in the opener and extend their franchise-best winning streak to 24 games.

With Golden State losing Lee to a torn hip flexor and the Nuggets getting top rebounder and energizer Kenneth Faried back from a sprained ankle, this one looked like a mismatch, even Curry acknowledged.

And it was, only not the way the Pepsi Center crowd anticipated.

"We're a resilient team, said that all year. When guys go down, other guys step up," said Curry, who played through a tender left ankle after turning it late in the third quarter. "We showed that tonight. Big road win for us. We've got to go home and protect our homecourt."

Even without their All-Star, the Warriors outrebounded the Nuggets 36-26.

"We didn't do much of anything very well," Nuggets coach George Karl lamented. "I don't think I ever coached a game when a team got three 35-point quarters, maybe in my career. Ever."

The best anybody shot against Denver during the season was 54 percent, by the Los Angeles Lakers way back on Nov. 20, and the most points the Nuggets had allowed was 126 at San Antonio on Nov. 17.

Ty Lawson and Corey Brewer each scored 19 points for Denver and Iguodala and Miller both had 18, but the Nuggets were playing catch-up from the middle of the second quarter and couldn't keep up with so many of the Warriors' shots falling, negating Denver's league-best transition game.

Lee led the league in double-doubles with 56 and had another before getting hurt in the fourth quarter of the series opener on Saturday. The Warriors were 3-18 without him over the last three seasons, but Jackson mixed and matched his lineup to make up for his All-Star's absence on this night, when Lee gave advice to his teammates during timeouts.

The Nuggets were hoping the return of Faried would help them reverse their 10-point disadvantage on the boards in Game 1. But he was rusty and the same problems that plagued Denver in the opener ? missing too many open shots, getting outmuscled on the glass and giving up open 3s ? haunted them once again and even more so.

Curry scored 15 points in the second quarter and hit four jumpers during a 14-5 run the Warriors used to grab control and take the air out of the Pepsi Center as they cruised into halftime with a 61-53 lead that would never be threatened in the second half.

Curry swished another sweet jumper to start the third quarter and the Warriors opened up a 17-point lead they would stretch to 20 in the fourth quarter.

"The game plan tonight was to keep the ball out of Stephen Curry's hands, but he came off (the pick-and-rolls) and had open looks and then he started finding people," Lawson said. "After that, we started scrambling and we can't play like that."

The Nuggets pulled within 76-69, but Thompson hit a 3-pointer from the right corner and Curry a 3 from the left to make it 82-69. Both were wide open as Denver's mismatched defenders were again running ragged trying to keep up with the Warriors, who handled the altitude just fine.

Denver got its deficit down to 115-105 but this time it was Jack's turn to make a wide-open 3 with the Nuggets defenders scrambling around.

Faried finished with four points and two rebounds in 21 minutes.

The arena was half-empty by the time the horn sounded, a solitary fan yelling derisively, "Tacos!" when Evan Fournier's free throw fell through the hoop to give the Nuggets 110 points, the magic number for a promotion in which fans get discounted tacos.

Notes: The Warriors shot a sizzling 61 percent in the first half, when they outrebounded the Nuggets 21-14. ... The Nuggets' last loss at home was 112-108 to the Washington Wizards on Jan. 18. ... Denver had just eight fast-break points, compared to Golden State's 14. ... Curry's 30-10 playoff game was the first for the franchise since Sleepy Floyd on May 10, 1987.

___

Follow Arnie Melendrez Stapleton on Twitter: http://twitter.com/arniestapleton

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Source: http://www.huffingtonpost.com/2013/04/24/warriors-nuggets-game-2-playoffs-curry_n_3143882.html

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Gut bacteria byproduct predicts heart attack and stroke

Apr. 24, 2013 ? A microbial byproduct of intestinal bacteria contributes to heart disease and serves as an accurate screening tool for predicting future risks of heart attack, stroke and death in persons not otherwise identified by traditional risk factors and blood tests, according to Cleveland Clinic research published today in The New England Journal of Medicine.

The research team was led by Stanley Hazen, M.D., Ph.D., Vice Chair of Translational Research, Chair of the Department of Cellular and Molecular Medicine for the Lerner Research Institute and section head of Preventive Cardiology & Rehabilitation in the Miller Family Heart and Vascular Institute at Cleveland Clinic, and W.H. Wilson Tang, M.D., Department of Cardiovascular Medicine in the Miller Family Heart and Vascular Institute and Lerner Research Institute.

The current study is an extension of Dr. Hazen's previous work, in which he found that a chemical byproduct called trimethylamine N-oxide (TMAO) is produced when intestinal bacteria digest the nutrient phosphatidylcholine, commonly known as lecithin. The prior research showed that TMAO levels in the blood were associated with heart disease. Dr. Hazen and colleagues have now confirmed that gut flora are essential in forming TMAO in humans and demonstrated a relationship between TMAO levels and future cardiac events like heart attack, stroke, and death -- even in those with no prior evidence of cardiac disease risk.

To demonstrate the role of gut flora in forming TMAO, human subjects were asked to eat two hard-boiled eggs (a common dietary source of lecithin) and a capsule of labeled lecithin (as a tracer). After ingestion, TMAO levels in the blood increased. However, when these same subjects were given a brief course of broad-spectrum antibiotics to suppress their gut flora, their TMAO levels were suppressed, and no additional TMAO was formed, even after ingesting lecithin. These results demonstrated that the intestinal bacteria are essential for the formation of TMAO.

In the second phase of the study, the researchers measured TMAO levels in a large, independent, clinical cohort -- consisting of more than 4,000 adults undergoing cardiac evaluation at Cleveland Clinic -- over a three-year follow-up period. They found that higher TMAO blood levels were associated with higher future risks of death and nonfatal heart attack or stroke over the ensuing three-year period, independent of other risk factors and blood test results. These results complement those of another recent study of Dr. Hazen's linking gut flora metabolism of a structurally similar nutrient found in animal products, carnitine, to TMAO production and heart attack risk.

"Heart disease remains the No. 1 killer, and while we know how to reduce cholesterol, treat blood pressure, and reduce cardiac risks through diet and other interventions, a substantial residual risk still remains," Dr. Hazen said. "We need to find new pathways to attack heart disease, and these findings strongly suggest that further research into the involvement of gut microbiome in the development of cardiovascular disease could lead to new avenues of prevention and treatment of heart disease."

Dr. Hazen further suggested, "These studies show that measuring blood levels of TMAO could serve as a powerful tool for predicting future cardiovascular risk, even for those without known risk factors. More studies are needed to confirm that TMAO testing, like cholesterol, triglyceride or glucose levels, might help guide physicians in providing individualized nutritional recommendations for preventing cardiovascular disease. Our goal is not to suggest dietary restrictions of entire food groups. Eggs, meat and other animal products are an integral part of most individuals' diets. Our work shows, however, that when digesting these foods, gut flora can generate a chemical mediator, TMAO, that may contribute to cardiovascular disease."

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The above story is reprinted from materials provided by Cleveland Clinic, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

W.H. Wilson Tang, Zeneng Wang, Bruce S. Levison, Robert A. Koeth, Earl B. Britt, Xiaoming Fu, Yuping Wu, Stanley L. Hazen. Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk. New England Journal of Medicine, 2013; 368 (17): 1575 DOI: 10.1056/NEJMoa1109400

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/D14BpEQC7uQ/130424185211.htm

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Geoscientists predict new compounds could change our view of what planets are made of

Apr. 24, 2013 ? A team of researchers led by Artem R. Oganov, a professor of theoretical crystallography in the Department of Geosciences, has made a startling prediction that challenges existing chemical models and current understanding of planetary interiors -- magnesium oxide, a major material in the formation of planets, can exist in several different compositions. The team's findings, "Novel stable compounds in the Mg-O system under high pressure," are published in the online edition of Physical Chemistry Chemical Physics. The existence of these compounds -- which are radically different from traditionally known or expected materials -- could have important implications.

"For decades it was believed that MgO is the only thermodynamically stable magnesium oxide, and it was widely believed to be one of the main materials of the interiors of the Earth and other planets," said Qiang Zhu, the lead author of this paper and a postdoctoral student in the Oganov laboratory.

"We have predicted that two new compounds, MgO₂ and Mg₃O₂, become stable at pressures above one and five million atmospheres, respectively. This not only overturns standard chemical intuition but also implies that planets may be made of totally unexpected materials. We have predicted conditions (pressure, temperature, oxygen fugacity) necessary for stability of these new materials, and some planets, though probably not the Earth, may offer such conditions," added Oganov.

In addition to their general chemical interest, MgO₂ and Mg₃O₂ might be important planet-forming minerals in deep interiors of some planets. Planets with these compounds would most likely be the size of Earth or larger.

The team explained how its paper predicted the structures in detail by analyzing the electronic structure and chemical bonding for these compounds. For example, Mg₃O₂ is forbidden within "textbook chemistry," where the Mg ions can only have charges "+2," O ions are "-2, and the only allowed compound is MgO. In the "oxygen-deficient" semiconductor Mg₃O₂, there are strong electronic concentrations in the "empty space" of the structure that play the role of negatively charged ions and stabilize this material. Curiously, magnesium becomes a d-element (i.e. a transition metal) under pressure, and this almost alchemical transformation is responsible for the existence of the "forbidden" compound Mg₃O₂.

The findings were made using unique methods of structure prediction, developed in the Oganov laboratory. "These methods have led to the discovery of many new phenomena and are used by a number of companies for systematically discovering novel materials on the computer -- a much cheaper route, compared to traditional experimental methods," said Zhu.

"It is known that MgO makes up about 10 percent of the volume of our planet, and on other planets this fraction can be larger. The road is now open for a systematic discovery of new unexpected planet-forming materials," concluded Oganov.

This work is funded by the National Science Foundation and DARPA.

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The above story is reprinted from materials provided by Stony Brook University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Qiang Zhu, Artem R. Oganov, Andriy O. Lyakhov. Novel stable compounds in the Mg?O system under high pressure. Physical Chemistry Chemical Physics, 2013; DOI: 10.1039/C3CP50678A

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/biochemistry/~3/e0dYr5OduAk/130424125444.htm

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Wednesday, April 24, 2013

Warriors cruise past Nuggets 131-117

Golden State Warriors forward Carl Landry, left, works ball inside as Denver Nuggets forward Wilson Chandler covers in the third quarter of the Warriors' 131-117 victory in Game 2 of the teams' NBA first-round playoff series in Denver on Tuesday, April 23, 2013. (AP Photo/David Zalubowski)

Golden State Warriors guard Klay Thompson, right, reahes out to pull in a loose ball as Denver Nuggets forward Corey Brewer covers in the fourth quarter of the Warriors' 131-117 victory in Game 2 of the teams' NBA first-round playoff series in Denver on Tuesday, April 23, 2013. (AP Photo/David Zalubowski)

Golden State Warriors head coach Mark Jackson questions a call against his team in the fourth quarter of the Warriors' 131-117 victory over the Denver Nuggets in Game 2 of the teams' NBA first-round playoff series in Denver on Tuesday, April 23, 2013. (AP Photo/David Zalubowski)

Denver Nuggets forward Anthony Randolph, front, hangs from the rim after dunking the ball for a basket as Golden State Warriors guard Klay Thompson, back left, and forward Harrison Barnes look on in the fourth quarter of the Warriors' 131-117 victory in Game 2 of the teams' NBA first-round playoff series in Denver on Tuesday, April 23, 2013. (AP Photo/David Zalubowski)

Golden State Warriors guard Jarrett Jack reacts to a catcall from a fan in the fourth quarter of the Warriors' 131-117 victory over the Denver Nuggets in Game 2 of the teams' NBA first-round playoff series in Denver on Tuesday, April 23, 2013. (AP Photo/David Zalubowski)

DENVER (AP) ? David Lee went from Golden State's All-Star power forward and double-double machine to the Warriors' biggest cheerleader and strategic adviser during timeouts.

Mostly, though, he just sat back and enjoyed the show Tuesday night when the Warriors stunned the Denver Nuggets 131-117 to even their playoff series at a game each.

The Warriors hardly missed much of anything. Not many of their shots, and not even their injured All-Star, who is out for the rest of the playoffs with a torn right hip flexor.

Behind Stephen Curry's 30 points and 13 assists, the Warriors became the first opponent to walk off the Pepsi Center court a winner since the Washington Wizards on Jan. 18.

The Warriors also got 26 points from surprise starter Jarrett Jack, a career-high 24 from rookie Harrison Barnes in his debut at power forward and 21 from Klay Thompson.

Most importantly, the sixth-seeded Warriors, who became the second road team to win in the postseason following Chicago's victory at Brooklyn on Monday, wrested home-court advantage from the NBA's best home team.

"They were knocking down shots," Denver's Andre Iguodala said.

That's an understatement. They were knocking them down better than they ever had before in a playoff game, a franchise playoff-record 64.6 percent from the field (51 of 79).

Every one of the nine Warriors who took at least a shot made better than half of them.

"Man, they were knocking it down," Ty Lawson marveled.

And it was, only not the way the Pepsi Center crowd anticipated.

Even without their All-Star, the Warriors outrebounded the Nuggets 36-26.

"We didn't do much of anything very well," Nuggets coach George Karl lamented. "I don't think I ever coached a game when a team got three 35-point quarters, maybe in my career. Ever."

The best anybody shot against Denver during the season was 54 percent, by the Los Angeles Lakers way back on Nov. 20, and the most points the Nuggets had allowed was 126 at San Antonio on Nov. 17.

Curry scored just one bucket, a 3-pointer, after turning his ankle but said he doesn't expect it to be an issue Friday night when the series shifts back to Oakland for Game 3.

Lawson and Corey Brewer each scored 19 points for Denver and Iguodala and Miller both had 18, but the Nuggets were playing catch-up from the middle of the second quarter and couldn't keep up with so many of the Warriors' shots falling, negating Denver's league-best transition game.

Curry swished another sweet jumper to start the third quarter and the Warriors opened up a 17-point lead they would stretch to 20 in the fourth quarter.

Asked if he thought the Nuggets were overconfident with Faried back and Lee down, Jack said: "They're confident for a good reason. They're a great team, especially playing in this building where they've only lost three games. I would be confident too. I don't think that's a shot at us, but they're back at full strength.

"If we were at full strength we'd be confident, as well. This by no means is a celebratory situation for us. We still have to come in and take care of business Friday."

Notes: Faried finished with four points and two rebounds in 21 minutes. ... Curry's 30-10 playoff game was the first for the franchise since Sleepy Floyd on May 10, 1987. He's the third NBA player since 2000 (Dwyane Wade and Chris Paul ? twice) to post 30 points, 13 assists and five rebounds in a playoff game. ... Carl Landry was introduced as a starter but Jack was summoned just before tip-off instead. ... Lawson had a career playoff-best 12 assists. ... With 14 points off the bench, Nuggets F Anthony Randolph had a career playoff-high 14 points. ... The last time the Nuggets surrendered 20-plus points to four players in a playoff game was on May 17, 1985, to the Lakers (James Worthy 28, Kareem Abdul-Jabbar 27, Byron Scott 21, Michael Cooper 20).

___

Follow Arnie Melendrez Stapleton on Twitter: http://twitter.com/arniestapleton

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-04-24-BKN-Warriors-Nuggets-Folo/id-84f68d446f40461e8a7c9b6c48707bd5

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Some Immigration Opponents Shy Away from Boston Talk

The specter of the Boston Marathon bombings ? and the fact that they were allegedly carried out by two immigrants to the United States ? continues to hang over the immigration reform efforts underway in the Senate.

A seven-hour hearing before the Senate Judiciary Committee Monday showed that those opposed to the Gang of Eight?s legislation seem willing to point to national security concerns as a reason to delay or significantly alter the immigration bill.

?The background checks in this bill are insufficient to prevent a terrorist from getting the amnesty,? argued Kris Kobach, the Kansas Secretary of State who helped author Arizona?s famously strict immigration law. ?The Tamerlan Tsarnaev example demonstrates how important an alien's ability to have freedom of movement and to travel abroad for terrorist connections and terrorist training is and how dangerous it can be for Americans,? he said, referring to one of the men suspected in the Boston bombings.

Mark Krikorian, the executive director of the Center for Immigration Studies who advocates for lower immigration levels, raised questions about why the Tsarnaev brothers were given visas to come to the U.S. in the first place.

?The Boston bombing is not an excuse for delay of considering this immigration bill, but it is an illustration of certain problems that exist with our immigration system,? he said. ?What does it say about the automated background checks that this bill would subject 11 million illegal immigrants to, that in-person interviews by FBI agent of Tamerlan Tsarnaev resulted in no action, even though it was actually based on concerns about terrorism??

But the Republican lawmakers who have expressed opposition to aspects of the Gang of Eight?s bill declined to follow up on the Boston-related sections of Kobach?s and Krikorian?s testimony. Instead, Sens. Chuck Grassley, R-Iowa, John Cornyn, R-Texas, Jeff Sessions, R-Ala., and Mike Lee, R-Utah, focused on other issues, ranging from border security to the legalization provisions.

Grassley in particular was so averse to being accused of saying the bombings should delay reform that he got in a shouting match with Sen. Chuck Schumer, D-N.Y., early in the hearing.

?I never said that,? Grassley shouted, with no small measure of indignation, when Schumer referenced his colleagues, ?who are pointing to what happened, the terrible tragedy in Boston? as an ?excuse for not doing a bill or delaying it.?

Schumer then said he wasn?t referring to Grassley, who at the start of Friday?s hearing on the bill said a close look at the immigration system was very important,?"particularly in light of all that's happening in Massachusetts right now and over the last week."

Democrats and members of the Gang of Eight have been going on the offensive against anyone suggesting that the bill?s passage should be slowed because of the bombings. Senate Judiciary Committee Chairman Patrick Leahy, D-Vt., opened the hearing by saying he was ?troubled a great deal? by opponents of the bill who ?began to exploit the Boston Marathon bombing.?

?Let no one be so cruel as to try to use the heinous acts of these two young men last week to derail the dreams and futures of millions of hardworking people,? he said. ?The bill before us would serve to strengthen our national security by allowing us to focus our border security and enforcement efforts against those who do us harm.?

Sen. Lindsey Graham, R-S.C., a member of the Gang of Eight, said, ?If Boston tells us anything, we need to be aware of who's living among us, whether they're native-born or come in on a visa and become a citizen.?

House Speaker John Boehner, R-Ohio, said Monday on Fox News: ?I?m in the camp of, if we fix our immigration system, it may actually help us understand who all?s here, why they?re here, and what legal status they have.?

That?s not to say there haven?t been Republicans who argued for a delay after the bombings. They just don?t sit on the Judiciary Committee.

Sen. Rand Paul, R-Ky., who has outlined his own vision for comprehensive reform, penned a letter to Senate Majority Leader Harry Reid, D-Nev., Monday, asking that national security concerns be a part of the debate going forward.

?We should not proceed until we understand the specific failures of our immigration system,? he wrote. ?Why did the current system allow two individuals to immigrate to the United States from the Chechen Republic in Russia, an area known as a hotbed of Islamic extremism, who then committed acts of terrorism? Were there any safeguards? Could this have been prevented? Does the immigration reform before us address this??

He called for hearings in the Senate Senate Homeland Security and Government Affairs Committee to study the national security aspect of the debate.

Two key House Republicans also backed up the Gang of Eight members on Monday by saying that immigration reform could improve national security.

Source: http://news.yahoo.com/immigration-opponents-shy-away-boston-talk-072350556--politics.html

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Screening detects ovarian cancer using neighboring cells

Apr. 22, 2013 ? Pioneering biophotonics technology developed at Northwestern University is the first screening method to detect the early presence of ovarian cancer in humans by examining cells easily brushed from the neighboring cervix or uterus, not the ovaries themselves.

A research team from Northwestern and NorthShore University HealthSystem (NorthShore) conducted an ovarian cancer clinical study at NorthShore. Using partial wave spectroscopic (PWS) microscopy, they saw diagnostic changes in cells taken from the cervix or uterus of patients with ovarian cancer even though the cells looked normal under a microscope.

The results have the potential to translate into a minimally invasive early detection method using cells collected by a swab, exactly like a Pap smear. No reliable early detection method for ovarian cancer currently exists.

In previous Northwestern-NorthShore studies, the PWS technique has shown promising results in the early detection of colon, pancreatic and lung cancers using cells from neighboring organs. If commercialized, PWS could be in clinical use for one or more cancers in approximately five years.

The ovarian cancer study was published this month by the International Journal of Cancer.

PWS uses light scattering to examine the architecture of cells at the nanoscale and can detect profound changes that are the earliest known signs of carcinogenesis. These changes can be seen in cells far from the tumor site or even before a tumor forms.

"We were surprised to discover we could see diagnostic changes in cells taken from the endocervix in patients who had ovarian cancer," said Vadim Backman, who developed PWS at Northwestern. "The advantage of nanocytology -- and why we are so excited about it -- is we don't need to wait for a tumor to develop to detect cancer."

Backman is a professor of biomedical engineering at the McCormick School of Engineering and Applied Science. He and his longtime collaborator, Hemant K. Roy, M.D., formerly of NorthShore, have been working together for more than a decade and conducting clinical trials of PWS at NorthShore for four years. Backman and Roy both are authors of the paper.

"The changes we have seen in cells have been identical, no matter which organ we are studying," Backman said. "We have stumbled upon a universal cell physiology that can help us detect difficult cancers early. If the changes are so universal, they must be very important."

Ovarian cancer, which ranks fifth in cancer fatalities among American women, usually goes undetected until it has spread elsewhere. The cancer is difficult to treat at this late stage and often is fatal.

"This intriguing finding may represent a breakthrough that would allow personalization of screening strategies for ovarian cancer via a minimally intrusive test that could be coupled to the Pap smear," Roy said.

At the time of the ovarian cancer study, Roy was director of gastroenterology research at NorthShore and worked with Jean A. Hurteau, M.D., a gynecological oncologist at NorthShore. (Hurteau is an author of the paper.) Roy is now chief of the section of gastroenterology at Boston University School of Medicine and Boston Medical Center.

The study included a total of 26 individuals. For cells taken from the endometrium (part of the uterus), there were 26 patients (11 with ovarian cancer and 15 controls); for cells taken from the endocervix, there were 23 patients (10 with ovarian cancer and 13 controls). The small size of the study reflects the difficulty in recruiting ovarian cancer patients.

Cells were placed on slides and then examined using PWS. The results showed a significant increase in the disorder of the nanoarchitecture of epithelial cells obtained from cancer patients compared to controls for both the endometrium and endocervix studies.

The cells for the ovarian cancer study were taken from the cervix and uterus. For the earlier lung cancer study, cells were brushed from the cheek. For the colon, cells came from the rectum, and for the pancreas, cells came from the duodenum. Cells from these neighboring organs showed changes at the nanoscale when cancer was present.

PWS can detect cell features as small as 20 nanometers, uncovering differences in cells that appear normal using standard microscopy techniques. PWS measures the disorder strength of the nanoscale organization of the cell, which is a strong marker for the presence of cancer in the organ or in a nearby organ.

The PWS-based test makes use of the "field effect," a biological phenomenon in which cells located some distance from the malignant or pre-malignant tumor undergo molecular and other changes.

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The above story is reprinted from materials provided by Northwestern University, via EurekAlert!, a service of AAAS.

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Journal Reference:

Dhwanil Damania, Hemant K. Roy, Dhananja Kunte, Jean A. Hurteau, Hariharan Subramanian, Lusik Cherkezyan, Nela Krosnjar, Maitri Shah, Vadim Backman. Insights into the field carcinogenesis of ovarian cancer based on the nanocytology of endocervical and endometrial epithelial cells. International Journal of Cancer, 2013; DOI: 10.1002/ijc.28122

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/OR6G5mqaHdM/130422175832.htm

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